منابع مشابه
RB in glutamine metabolism
In a majority of cancer cells, inactivation of the retinoblastoma protein (pRB) through hyperphosphorylation, deletion, or mutation leads to dissociation from E2F effector proteins and aberrant activation of downstream target genes. Suppression of pRB function ultimately results in the loss of regulatory control over multiple biochemical pathways required for tumorigenesis, including cell cycle...
متن کاملGlutamine Transport and Mitochondrial Metabolism in Cancer Cell Growth
The concept that cancer is a metabolic disease is now well acknowledged: many cancer cell types rely mostly on glucose and some amino acids, especially glutamine for energy supply. These findings were corroborated by overexpression of plasma membrane nutrient transporters, such as the glucose transporters (GLUTs) and some amino acid transporters such as ASCT2, LAT1, and ATB0,+, which became pro...
متن کاملInhibition of glutamine uptake regulates mTORC1, glutamine metabolism and cell growth in prostate cancer
Background Amino acids such as glutamine are important for tumor cell growth, survival and metabolism. There is renewed interest in glutamine metabolism due to the importance of reductive carboxylation in cancer. The amino acid transporter ASCT2 (SLC1A5) mediates uptake of glutamine in cancer cells. We have recently reported that ASCT2 expression is significantly upregulated in melanoma, and AS...
متن کاملAvian mitochondrial glutamine metabolism.
Intact avian liver mitochondria were shown to synthesize glutamine from glutamate in the absence of exogenous ATP and ammonia. With L-[U-14C]glutamate as the substrate, there was an approximate 1:1 stoichiometry between glutamate deaminated (as measured by the release of 14CO2 due to alpha-keto-[14C]glutarate oxidation) and glutamate amidated. With L-[15N]glutamate as the substrate, the isolate...
متن کاملGlutamine Metabolism: Nutritional and Clinical Significance Glutamine Metabolism in Sepsis and Infection
Severe infection causes marked derangements in the flow of glutamine among organs, and these changes are accompanied by significant alterations in regional cell membrane transport and intracellular glutamine metabolism. Skeletal muscle, the major repository of glutamine, exhibits a twofold increase in glutamine release during infection, which is associated with a significant increase in endogen...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Experimental & Molecular Medicine
سال: 2020
ISSN: 1226-3613,2092-6413
DOI: 10.1038/s12276-020-00504-8